Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 11

年份

2024 1

2018 1

2017 1

2016 1

2015 1

2014 1

2013 1

2011 1

2009 1

2007 2

展开︾

关键词

器官短缺 1

城市主干道；控制子区；协调控制；关联度；模糊逻辑；智能交通 1

扩大标准供体 1

机械灌注+ 1

肝移植 1

展开︾

检索范围：

排序：展示方式：

Contemporary coronary artery bypass grafting

null

《医学前沿（英文）》 2014年第8卷第4期页码 395-398 doi: 10.1007/s11684-014-0374-7

摘要：

Current evidence clearly demonstrates that coronary artery bypass grafting (CABG) remains the “gold standard” treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

关键词： coronary artery bypass grafting (CABG) coronary artery disease left main arterial grafts internal mammary artery off-pump CABG

HTML PDF 收藏

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

《医学前沿（英文）》 2011年第5卷第3期页码 248-253 doi: 10.1007/s11684-011-0149-3

摘要： Chronic allograft vasculopathy (CAV) remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years. CAV is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of lymphocyte or inflammatory cells, and deposition of extracellular matrix both in arteries and veins. Recent studies have shown that stem cells derived from the recipient contribute to neointimal formation under the regulation of chemokines and cytokines. Arterial remodeling in allografts eventually causes ischemic graft failure. The pathogenesis is multi-factorial with both immunologic and non-immunological factors being involved. The immunological factors have been discussed extensively in other articles. This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury, accumulation of smooth muscle-like cells in the neointimal, medial smooth muscle cell apoptosis, adventitial fibrosis, and deposition of extracellular matrix.

关键词： transplantation chronic rejection neointimal immunology arterial remodeling allograft vasculopathy

HTML PDF 收藏

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年第11卷第3期页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPI^Flox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPI^Sma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPI^Sma mice compared with TFPI^Flox littermate controls. Plasma TFPI concentration was also detected in the TFPI^Tie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPI^Tie2 mice was 80.4% lower (P<0.001) than that of the TFPI^Flox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPI^Sma and TFPI^Flox mice. However, TFPI^Sma mice had increased ferric chloride–induced arterial thrombosis compared with TFPI^Flox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells

HTML PDF 收藏

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

《机械工程前沿（英文）》 2009年第4卷第3期页码 300-304 doi: 10.1007/s11465-009-0038-5

摘要： To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequency, a linear-elastic and small deformation condition is assumed. The theoretical analysis is first presented and the finite element method is then used to numerically simulate the spatial kinematics. The results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions agree well with numerical solutions, which proves that the theoretical analysis and numerical simulation are both correct.

关键词： spatial kinematics natural frequency finite element method

HTML PDF 收藏

Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

《医学前沿（英文）》 2007年第1卷第1期页码 68-73 doi: 10.1007/s11684-007-0014-6

摘要： The association of metabolic syndrome (MS) with arterial compliance in children and adolescents was explored. 337 subjects (188 men and 149 women) aged 6 18 (10.95?3.01) years, out of Beijing Child Metabolic Syndrome Study , were divided into three case groups (one component, two components, three & more components of MS) and one control group based on the Cook s MS definition in children and adolescents. Measurements including anthropometry, blood pressure, fasting plasma glucose and insulin, serum lipid profile were done. Homeostasis model assessment for insulin resistance (HOMA-IR) index was calculated for estimating individual insulin resistance. Arterial compliance was measured using digital pulse wave analyzing method from the pulse trace machine (Micro medical, London), and then the stiffness index (SI) was determined. The mean value of SI in MS group was significant higher than that in control group [(7.69?1.63) vs (6.25?0.86) m/s, <0.01]. With the increase of the clustering of MS components, SI and HOMA-IR were gradually increased. After taking account of gender, age and pubertal development, the partial correlation analysis showed that the amount of components of MS and HOMA-IR were positively correlated with SI (both values were less than 0.05). The arterial compliance of MS group was significantly lowered in children and adolescents, and with the increase of the clustering of MS components, arterial compliance was gradually decreased. It was suggested that arterial compliance assessment in children and adolescents was important for early prevention of cardiovascular diseases.

关键词： compliance assessment correlation analysis cardiovascular clustering HOMA-IR

HTML PDF 收藏

Progress and perspectives of neural tissue engineering

null

《医学前沿（英文）》 2015年第9卷第4期页码 401-411 doi: 10.1007/s11684-015-0415-x

摘要：

Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.

关键词： nerve injury tissue engineering nerve grafts

HTML PDF 收藏

Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city

Mbakisya ONYANGO, Saliha Ammour MERABTI, Joseph OWINO, Ignatius FOMUNUNG, Weidong WU

《结构与土木工程前沿（英文）》 2018年第12卷第3期页码 291-299 doi: 10.1007/s11709-017-0419-5

摘要：

Many transportation agencies lack sufficient funds to maintain and repair roads, which results into increased pavement maintenance cost. Pavement Management System (PMS) has demonstrated to be an essential tool for proper management of infrastructure and proper utilization of available funds. The University of Tennessee at Chattanooga utilized Micropaver software as PMS tool to conduct a pavement management analysis of principal arterials in the City of Chattanooga. The study used the City of Chattanooga pavement database to create the current and future pavement conditions. Maintenance and repair (M&R) planning analysis was also performed in order to determine the most cost-effective treatment and suggest the optimum utilization of funds for the city. An analysis of five budget scenarios was conducted for a five-year plan using the critical pavement condition index (PCI) method (ASTM D6433). Results show that the backlog elimination budget would be the best scenario because it increases the pavement condition and eliminates the backlog of major maintenance and repairs over the five-year period. The unlimited budget seems though ideal, it does not improve pavement condition. Maintaining current condition and limited budget scenarios would increase both the backlog and the total cost of maintenance and repairs over the analysis period.

关键词： PMS Micropaver pavement budget maintenance rehabilitation

HTML PDF 收藏

Partial portacaval shunt with H-grafts to treat portal hypertension

XU Geliang, HU Hejie, LI Jiansheng, YANG Shugao, CHAI Zhongpei, XU Rongnan

《医学前沿（英文）》 2007年第1卷第3期页码 279-281 doi: 10.1007/s11684-007-0053-z

摘要： Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity (especially encephalopathy, liver failure and occlusion). The results of partial portacaval shunts [small-diameter expanded polytetrafluoroethylene (ePTFE) H-graft portacaval shunt] were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension. Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006. Thirty-three had externally ringed grafts and ten had non-ringed ones. Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm. The left gastric artery and coronary vein were ligated in all the cases. Six had pericardial devascularization and splenectomy was performed in 42. An average decrease of free portal pressure (FPP) from (33.24 ± 4.78) cmHO before shunting and (13.65 ± 5.65) cmHO after shunting was observed. The portal blood flow was reduced by one-third of that before shunt. Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period (50.5 months in average). Two were out of contact. Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases (3/41, 7.3%). Encephalopathy developed in five cases (5/41, 12.2%). Partial (small-diameter ePTFE H-graft) portacaval shunting can reduce the portal pressure effectively. Majority of the hepatic flow from the portal vein can be maintained adequately. The shunts with reinforced grafts can keep a higher rate of patency. The morbidity of encephalopathy was lower than those with total shunt. The partial portacaval shunt is effective in preventing recurrent variceal bleeding.

关键词： diameter clinical efficacy bleeding pericardial devascularization Forty-three

HTML PDF 收藏

一种城市主干道信号动态协调控制方法及其应用 Article

Guo-jiang SHEN,Yong-yao YANG

《信息与电子工程前沿（英文）》 2016年第17卷第9期页码 907-918 doi: 10.1631/FITEE.1500227

摘要：概要：针对城市主干道的交通流特征，提出了一种新的交通信号协调控制方法。其核心控制算法包括两个模块：控制子区划分模块和信号协调控制模块。本文首先分析了相邻交叉口的路段长度、路段交通密度以及交叉口信号配时参数对相邻交叉口交通关联度的影响，然后设计了基于分层结构的相邻交叉口交通关联度的模糊计算方法和基于关联度的主干道控制子区划分方法。接着提出了一种控制子区协调控制算法，根据一段时间内交通流信息计算控制子区公共信号周期、路段上下行相位差和各路口的绿信比。实际应用表明该控制方法能有效降低主干道交通流平均旅行时间和平均停车率，效果令人满意。

关键词：城市主干道；控制子区；协调控制；关联度；模糊逻辑；智能交通

HTML PDF 收藏

Non-invasive continuous blood pressure monitoring: a review of current applications

null

《医学前沿（英文）》 2013年第7卷第1期页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring continuous blood pressure monitoring invasive blood pressure monitoring Riva-Rocci technique oscillometric Pe?áz technique arterial tonometry pulse transit time

HTML PDF 收藏

“机械灌注+”应用于扩大标准供肝移植——肝尽其用 Review

王周城, Jack Martin, 余炯杰, 汪恺, Kourosh Saeb-Parsy, 徐骁

《工程（英文）》 2024年第32卷第1期页码 30-41 doi: 10.1016/j.eng.2023.11.003

摘要：

移植是终末期肝病最有效的治疗方法，但由于供体器官的短缺而受到限制。扩大标准供体（ECD）供肝在临床实践中越来越多地用于缓解这一挑战。然而，这些移植物耐受缺血的能力下降，危及冷保存期间器官的活力。机器灌注（MP）旨在改善器官保存并减少移植后并发症。然而，越来越明显的是，单独使用MP无法达到ECD供肝的最佳保存。因此，人们逐渐开始重视改良的 MP 策略，包括使用不同的灌注剂、改良的灌注方式并结合不同的治疗干预策略。本文中，我们提出了“机械灌注+”的新理念，代表这些旨在提升器官功能并可能实现ECD供肝体外再生的机械灌注新策略。为此，我们总结了现有和改良的MP策略，并阐述其在临床场景中修复不同ECD供肝的优势。

关键词：肝移植扩大标准供体机械灌注+ 器官短缺